10th International Biomedical Research into ME Colloquium 2020

Former Dean of Biological Sciences, UEA

Dr Ian Gibson, former Labour MP for Norwich North, worked at University of East Anglia for 32 years, became Dean of the school of biological sciences in 1991 and was head of a cancer research team and set up the Francesca Gunn Leukaemia Laboratory at UEA. In 2011 Dr Gibson received an honorary doctorate of civil law from UEA.

Other Links

• IIMEC6 Pre-Conference Presentation Science, Politics.... and ME
• Gibson Inquiry into ME
• NICE WITNESS STATEMENT

Research Leader, Quadram Institute Bioscience, Norwich Research Park, UK

Upon completing postgraduate work at the Medical Research Council’s Clinical Research Centre in Harrow, I “emigrated” to the USA to take up a postdoctoral position at New York University School of Medicine, and then at Yale University as a Howard Hughes Fellow in the Immunobiology Group at Yale University with Profs Kim Bottomly and Charlie Janeway Jr. While at Yale an interest in gamma-delta (γδ) T cells was acquired working closely with Adrian Hayday on molecular genetics and then with Prof. Peter Doherty to establish their role in (viral) infectious disease. I left Yale after five years to take up a faculty position at the University of Pennsylvania in Philadelphia where I developed a research interest in mucosal and GI-tract immunology, performing studies in germfree mice with Prof John Cebra that helped establish the role of gut microbes in the aetiology of inflammatory bowel disease (IBD).

After 15 years in the USA, I returned to the UK to take up the Chair in Molecular Immunology at the University of Leeds where I established a new research programme on commensal gut bacteria and Bacteroides genetics leading to the development of a Bacteroides drug delivery platform that is being used for developing new interventions for IBD and for mucosal vaccination.

In 2008 I was recruited by UEA and IFR to develop a gut research programme, taking up the Chair of Mucosal Immunology at UEA-MED and the position of head of the Gut Biology Research Programme at IFR, which later became part of the Gut Health and Food Safety (GHFS) Programme. GHFS research covers a broad area of gut biology including epithelial cell physiology, mucus and glycobiology, mucosal immunology, commensal microbiology, foodborne bacterial pathogens, and mathematical modelling and bioinformatics. The success of this programme has led to the establishment of the Gut Microbes and Health research programme that is integral to the research agenda of The Quadram Institute.

Within these programmes, much of the work undertaken in my research group builds upon that carried out in the USA and latterly in the UK with a major focus on understanding the mechanisms of intestinal microbial (bacterial and viral) tolerance. In particular, identifying the pathways and mediators of microbe-host cross talk and the role they play in establishing and maintaining gut health and in diseases that not only affect the gut but other organ systems. This has led to the development of new research projects relating to the gut-microbiome-brain axis and understanding how the intestinal microbiome impacts on mental health and the development of neurodegenerative diseases, and the intestinal virome and the role that prokaryotic and eukaryotic viruses play in microbial homeostasis and dysbiosis.

Other Links

• Professor Simon Carding
• Invest in ME UK GUT MICROBIOTA RESEARCH

Other Links

• Professor Angela Vincent

Emeritus Professor of Neuroimmunology, University of Oxford

Professor Vincent is Emeritus Professor of Neuroimmunology at the University of Oxford, and an Emeritus Fellow of Somerville College. She holds an Honorary Consultant position in Immunology and runs the Clinical Neuroimmunology service which is an international referral centre for the measurement of antibodies in neurological diseases.

Together with colleagues she collaborates with neurologists worldwide. She was formerly Head of Department of Clinical Neurology (2005-2008), and is a Past President of the International Society of Neuroimmunology, and an Associate Editor of Brain.

She was a co-applicant and group leader of OXION, the Wellcome Trust-funded Integrative Physiology Initiative "Ion channels and Diseases of Electrically Excitable Cells". She is a member of Faculty of 1000 (Neuroscience, Neurobiology of Disease and Regeneration)

Her major interest is in the role of autoimmunity in neurological diseases, including multiple sclerosis and auto-antibody mediated ion channel and receptor disorders. Recent advances have included (a) the discovery that maternal antibodies to different fetal proteins can cause rare neuromuscular disorders, and may be involved in some forms of autism or other neurodevelopmental disorders; (b) the definition and characterisation of a new form of myasthenia gravis associated with antibodies to a receptor tyrosine kinase, MuSK, that performs an important maintenance role at the neuromuscular junction; and (c) the recognition that some central nervous system disorders, involving memory loss, seizures, movement disorders, can be caused by antibodies to potassium ion channels and to various receptor proteins.

In these, and several other conditions, new ways are being devised to measure the pathogenic antibodies for better clinical diagnosis, and establishing model in vitro and in vivo systems for investigation of the pathophysiology of the diseases. Her group also works, in collaboration with Profs David Beeson and Nick Willcox, on the genetics of myasthenia and the factors that determine autoimmune responses to the main target, the acetylcholine receptor.

Research Scientist, Department of Medical Microbiology & Immunology, University of Alberta, Canada

Dr Landi works at Professor Michael Houghton's laboratory in the Dept. of Medical Microbiology & Immunology at the University of Alberta, Canada. He is a member of the ME/CFS committee of the Alberta Medical Association and Research & Medical Advisor, National ME/FM Action Network, Canada.

Other Links

• Dr Amir Landi Research
• Dept. MMI, University of Alberta
• Professor Michael Houghton MMI Faculty, University of Alberta

Emeritus Professor of Connective Tissue Medicine University College London (UCL)

Professor Jonathan Edwards, of UCL's Department of Medicine, announced a highly original new treatment for rheumatoid arthritis in October 2000. His team has conducted trials of a new combination of drugs on patients who have suffered from rheumatoid arthritis for as long as 20 years; all but two of the 22 patients have so far shown marked improvements in their symptoms of the disease. More information IIMER Rituximab Clinical Trial for ME Professor Edwards has been the charity's advisor. He has played a major part in initiating the IiMER rituximab clinical trial project which IiMER and UCL initiated - click here

Other Links

• UCL Profile Professor Jonathan Edwards
• ResearchGate Jonathan Edwards
• IIMER UK Rituximab Trial Home Page

Associate Professor, Center for Infection and Immunity (CII), Columbia University Mailman School of Public Health New York, USA

Mady Hornig, MA, MD is a physician-scientist in the Center for Infection and Immunity (CII) at the Columbia University Mailman School of Public Health where she serves as Director of Translational Research and is an associate professor of epidemiology. Her research focuses on the role of microbial, immune, and toxic stimuli in the development of neuropsychiatric conditions, including autism, PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection), mood disorders and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). She is widely known both for establishing animal models that identify how genes and maturational factors interact with environmental agents to lead to brain disorders and for her work clarifying the role of viruses, intestinal microflora and xenobiotics in autism and other neuropsychiatric illnesses that may be mediated by immune mechanisms. Under her direction, proteomic analyses of umbilical cord samples are identifying potential birth biomarkers for autism in a prospective study in Norway, the Autism Birth Cohort (ABC). She established that there was no association between intestinal measles virus transcripts and autism, and, with Brent Williams and W. Ian Lipkin at CII, has found altered expression of genes relating to carbohydrate metabolism and inflammatory pathways and differences in the bacteria harboured in the intestines of children with autism. She also leads projects examining the influence of immune molecules on brain development and function and their role in the genesis of schizophrenia, major depression, and cardiovascular disease comorbidity in adults, and directs the Chronic Fatigue initiative Pathogen Discovery and Pathogenesis Project at CII. In 2004, Dr. Hornig presented to the Institute of Medicine Immunization Safety Review Committee and testified twice before congressional subcommittees regarding the role of infections and toxins in autism pathogenesis. Her work in ME/CFS is establishing immune profiles and helping to identify pathogens that may be linked to disease.

Other Links

• Associate Professor Mady Hornig

Principal Research Fellow Inflammation, Div of Medicine Faculty of Medical Sciences, UCL

Her group focuses its interests on B cell depletion (an idea which they introduced (with the Professor Jo Edwards) approximately 10 years ago for the treatment of rheumatoid arthritis), exploring more precisely how the technique works and trying to explain the marked variation in response between different patients.

Other Links

• UCL Dr Jo Cambridge
• Response to rituximab: has the original hypothesis been confirmed?
• B cell targeting in rheumatoid arthritis and other autoimmune disorders.
• IIMER UK Rituximab Trial Home Page

Consultant Clinical Immunology and Immunopathology Epsom and St Helier University Hospitals NHS Trust Surrey, UK

Dr. Bansal trained in immunology and allergy from 1989 to 1993 at St. Mary's Hospital in Manchester and at Hope Hospital in Salford. From here he spent five years (1993-1997) as Senior Lecturer and Consultant in Clinical Immunology in the Department of Medicine at the Princess Alexandra Hospital in Brisbane, Australia. From 1997 to the present date Dr. Bansal has worked as a Consultant in Clinical Immunology and Immunopathology at Epsom and St Helier University Hospital. Dr Bansal's key interests lie in allergy, autoimmunity, CFS/ME and immunodeficiency. Dr Bansal is involved in the gut microbiota study at UEA, the IIMER rituximab clinical trial and Autoimmunity and ME, a study involving the hypothalamus - all projects funded by Invest in ME. Research from Dr Bansal

Other Links

• Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls
• ResearchGate Jonathan Edwards
• IIMER UK Rituximab Trial Home Page
• IIMER/IFR UK Gut Microbiotas Project Home Page

Dr Øystein Fluge

Dr Øystein Fluge received medical degree in 1988 at the University of Bergen, and is a specialist in oncology since 2004. He has worked as a Research Fellow with support from the Norwegian Cancer Society and is now chief physician at the Cancer Department, Haukeland University Hospital. Doctoral work emanates from the Surgical Institute and Department of Molecular Biology, University of Bergen.

Other Links

• Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study
• New study on pathological mechanisms in ME from Bergen research group

Professor Olav Mella

Professor Mella has performed clinical trials to test the benefit of B-cell depletion therapy using Rituximab in ME/CFS patients. Dr. Olav Mella of Haukeland University Hospital in Bergen, Norway began his investigation of Rituximab’s effects on CFS after treating several Hodgkin’s Lymphoma patients who had long standing cases of CFS prior to developing cancer. Professor Mella and Dr Fluge have published a paper "Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study"

Other Links

• Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study
• Researchgate - Olav Mella Haukeland University Hospital, Bergen

Lecturer in the College of Medicine, Biological Sciences and Psychology at the University of Leicester

Claire Hutchinson is a vision scientist.

The majority of her work is concerned with how visual sensory information is encoded by the human visual system.

Her research includes healthy visual perception, age-related visual decline, and visual markers of 'non-visual' illnesses.

It is this latter strand of research that led her to study vision-related problems in ME/CFS.

Other Links

• University of Leicester
• Eye health could help diagnose people with chronic fatigue syndrome

Full Chair Professor in Analytical Chemistry and Neurochemistry at the Department of Chemistry, Uppsala University, Sweden

Professor Begquist has a background as MD, Associate Professor of Clinical Neuroscience , Sahlgrenska University Hospital and the University of Gothenburg. Since 1999 , he has been a researcher in Uppsala, Sweden, and in 2005 was appointed professor of analytical chemistry and neurochemistry at the Department of Chemistry - BMC , Uppsala University. From 2011 he worked also as an adjunct professor of pathology at the University of Utah, Salt Lake City, Utah, USA.

Other Links

• Uppsala University web site, Sweden
• Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome
• Establishing the Proteome of Normal Human Cerebrospinal Fluid

Director Institute of Food Research, Norwich, UK

Professor Ian Charles joined the Institute of Food Research in May 2015 to lead the programme to develop the UK’s new Centre for Food & Health to be based at the Norwich Research Park. Professor Charles returned to the UK from Australia where he was Director of the ithree institute, University of Technology, Sydney.
Professor Charles has over 30 years’ experience in academic and commercial research. His academic career has included being a founding member of The Wolfson Institute for Biomedical Research at University College London, one the UK’s first institutes of translational medicine. He has also worked in the pharmaceutical industry at Glaxo Wellcome, and has been founder and CSO of biotech companies in the area of infectious disease, including Arrow Therapeutics, sold to AstraZeneca, and Auspherix a venture capital backed company founded in 2013.
His current research interests include infectious diseases as well as the microbiome and its impact on health and wellbeing.
The new Centre for Food & Health will provide a step change for food and health research, and the translation of science by industry, to benefit society and the UK economy.
The Centre will be located at the Norwich Research Park, one of Europe’s largest single-site concentrations of research in Food, Health and Environmental sciences.
The multidisciplinary Centre aims to bring together the Institute of Food Research and aspects of the University of East Anglia’s Faculty of Science and the Norwich Medical School with the regional gastrointestinal endoscopy facility at the Norfolk and Norwich University Hospital. With a unique integration of diet, health, nutrition and medicine under one roof, linking closely to world class plant and crop research at the John Innes Centre and bioinformatics at The Genome Analysis Centre (both also located on the Norwich Research Park), it will have the potential to deliver clinically validated strategies to improve human health and wellbeing.

Other Links

• Leading scientist to develop new Centre for Food and Health and to head the Institute of Food Research

Invest in ME Research Students and Researchers
The Next Generation of Scientists

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Other Links

• Fane Mensah, UCL [ME/CFS – Through The Eyes of a Young Researcher]
• Navena Navaneetharaja, UEA/IFR [A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?]
• Verity Griffiths, UEA/IFR [A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?]
• Bharat Harbham, UEA A role for a leaky gut and the intestinal microbiota in the pathophysiology of myalgic encephalomyelitis
• Daniel Vipond, UEA/IFR [UK Gut Microbiota Research Update]
  Dysbiosis of the gut microbiota in disease

The National Centre for Neuroimmunology and Emerging Diseases (NCNED), Griffiths University, Australia

Professor Marshall-Gradisnik is one of Australia's foremost researchers in the area of neuroimmunology and has been instrumental in establishing the Public Health and Neuroimmunology Unit (PHANU) at Bond University. Much of her work relates specifically to autoimmunity in Chronic Fatigue Syndrome sufferers and she is regularly asked to speak to community groups on behalf of Queensland Health and NSW Health. Her research in the area of exercise immunology has also contributed to the body of knowledge relating to the effect of doping in sport and she serves as Sports Medicine Australia's national spokesperson in this area. The vital research conducted by Professor Marshall has attracted more than $1 million in grant funding and she has produced 21 peer-reviewed papers, five book chapters and one provisional patent. In 2008 Dr Marshall was joint leader of the Bond University team responsible for developing the the BioSMART program. The team was awarded a prestigious Australian Teaching and Learning Council Award (formerly known as the Carrick Award) for Outstanding Contribution to Student Learning and for the quality of student learning over a sustained period of time. Professor Marshall-Gradisnik is also leading The National Centre for Neuroimmunology and Emerging Diseases (NCNED), a research team situated at Griffith University on the Gold Coast. The team focuses on Myalgic Encephalomyelitis.

Other Links

• ResearchGate - Professor Sonya Marshall-Gradisnik
• National Centre for Neuroimmunology and Emerging Diseases

The National Centre for Neuroimmunology and Emerging Diseases (NCNED), Griffiths University, Australia

Professor Staines has been a public health physician at Gold Coast Population Health Unit. He has worked in health services management and public health practice in Australia and overseas. His interests include collaborative health initiatives with other countries as well as cross-disciplinary initiatives within health. Communicable diseases as well as post infectious fatigue syndromes are his main research interests. A keen supporter of the Griffith University Medical School, he enjoys teaching and other opportunities to promote awareness of public health in the medical curriculum. He is now Co-Director at The National Centre for Neuroimmunology and Emerging Diseases (NCNED), Griffiths University in Australia

Infectious Disease Specialist, Torrance, California, USA

Dr Chia is an infectious disease specialist practicing in Torrance, California, USA and has published research recently (Chronic fatigue syndrome associated with chronic enterovirus infection of the stomach) on the role of enteroviruses in the aetiolgy of ME/CFS – an area which has been implicated as one of the triggers by a number of studies.
There are more than 70 different types of enteroviruses that can affect the central nervous system, heart and muscles, all of which is consistent with the symptoms of ME/CFS. By analyzing samples of stomach tissue from 165 patients with CFS, Dr. Chia's team discovered that 82% of these individuals had high levels of enteroviruses in their digestive systems. Dr Chia's research may result in the development of antiviral drugs to treat the debilitating symptoms of ME/CFS.
Dr Chia is President of the Enterovirus Foundation and Assistant Professor at the UCLA School of Medicine.

Other Links

• Dr John Chia interview
• Enterovirus Foundation

Honorary Consultant Neuropsychiatrist, Brighton & Sussex Medical School, UK

Dr Harrison's' work in the laboratory focuses on understanding how infection or inflammation in the body interacts with the brain.
For most these symptoms are usually short lived and relatively mild. However, when the immune system is activated for long periods, such as in people suffering from rheumatoid arthritis, they can become extremely debilitating or even life-threatening.
Understanding how the immune system interacts with the brain is a crucial first step that will form the foundations for future development of novel therapies targeting these common and disabling symptoms.
Most of his studies utilise a combination of functional brain imaging (e.g. fMRI, FDG-PET, EEG, polysomnography), experimental models of inflammation, custom cognitive tasks and diverse measures of peripheral immune status.

Other Links

• Gray matter textural heterogeneity as a potential in-vivo biomarker of fine structural abnormalities in Asperger syndrome. Radulescu, E., Ganeshan, B., Minati, L., Beacher, F.D.C.C., Gray, M.A., Chatwin, C., Young, R.C.D., (...), Critchley, H.D. 2012 Pharmacogenomics Journal (in Press)

Ithaca College, USA

Professor Keller is Professor Ithaca College, Dept. of Exercise and Sport Sciences, Ithaca, NY.
RESEARCH / CLINICAL FOCUS: Since 2003 Professor Keller has tested persons ill with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) for purposes of research and/or to provide an objective assessment of functional capacity and ability to perform and recover from physical work. Often, these individuals seek an objective indication of illness status to apply for disability benefits. A two-day exercise test protocol has shown to be instrumental in delineating abnormal responses to and recovery from exercise in ME/CFS patients. Her report of test results and interpretation has been successful in many cases to support an argument for disability coverage.
There are only a few researchers in the USA who have performed and interpreted the two-day exercise test protocol on ME/CFS patients, and therefore have observed first-hand the anomalous multisystem responses of these patients 24 hours post-exercise.
Professor Keller continues to expand the small body of peer-reviewed evidence of the abnormal recovery response to physical activity in ME/CFS so that most, if not all clinicians, researchers, health insurers and patient family members also understand the deleterious impact of this illness.
To that end, She has collaborated on an NIH R21 grant with PI, Maureen Hanson, from Cornell University to study the effects of exercise in ME/CFS on parameters of physiological and immune function.
Together they continue to analyze this data and other data collected to better understand how to help those with ME/CFS.

Other Links

• Betsy Keller Profile
• Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment

Invest in ME are pleased to announce that giving a keynote speech at BMEC5 will be Professor David Brooks from Imperial College, London. Professor Brooks is Hartnett Professor of Neurology in the Department of Medicine.

Professor Brooks' research involves the use of positron emission tomography and magnetic resonance imaging to diagnose and study the progression of Alzheimer's and Parkinson's diseases in life and to validate imaging biomarkers for therapeutic trials.

Professor Brooks will be giving a keynote speech on Imaging Inflammation and Its Role in Neurodegeneration. This is important for understanding and evaluating the role of imaging in diagnostics and may aid researchers involved in ME-related imaging studies.

Professor David Brooks MD, DSc, FRCP, FMedSci

To date, Professor Brooks has published over 350 reports in peer reviewed journals, including Nature and has an h index of 97. His research is supported by grants from the EU FP7 programmes, UK Medical Research Council, the Alzheimer's Research Trust, Parkinson's UK, the Michael J Fox Foundation, Lundbeck Foundation, Danish Council for Independent Research, and industry. He is Chairman of the Executive Committee of the EMBL Nordic Hub at Aarhus University and is a member of the scientific advisory board of Alzheimer UK. He has been a member of the scientific advisory boards of the German Dementia and Parkinson networks, the Austrian KLIF Science Fund, the Research Advisory Panels of the UK Parkinson's Disease Society, Inserm, the Michael J. Fox Foundation (2002-2006), UK Medical Research Council Neuroscience and Mental Health Board (2004-2007), UK Huntington's Disease Association, and was Chairman of the Scientific Issues Committee of the Movement Disorder Society (1998-2002) and a Director of the International Society of Cerebral Blood Flow and Metabolism (1993-1997). He was Chairman of the Council of Management of the UK Parkinson's Disease Society 1997-8. He is an Associate Editor of Brain and on the Editorial Boards of Parkinsonism and Related Disorders, Basal Ganglia, Journal of Parkinson's Disease, Clinical Neurology and Neurosurgery, Synapse, Molecular Imaging and Biology, Journal of Neurotherapeutics, and Current Trends in Neurology. He was on the editorial boards of the Journal of Neural Transmission, Journal of Neurology, Neurosurgery, and Psychiatry and Movement Disorders. In 2001 he was elected a Fellow of the Academy of Medical Science, UK. In 2002 he was invited to give the Stan Fahn Lecture at the International Congress of Movement Disorders, Miami, in 2003 the George Cotzias Lecture in Madrid, in 2004 the Charles E Wilson Lecture, the Psychobiology Institute, Jerusalem March 2004, in 2005 the Kuhl-Lassen lecture at the Society of Nuclear Medicine, Toronto, and in 2006 the Sprague lecture at UC Irvine.

Professor David Brooks Bio

President of Sierra Internal Medicine, Nevada, USA

With over 25 years of medical practice, Dr Daniel L. Peterson has become a sought-after internist for diagnosing difficult and complex medical cases.

Daniel Peterson is an American physician in private practice in the state of Nevada, and has been described as a "pioneer" in the treatment of chronic fatigue syndrome (CFS).

He graduated from the University of Rochester School of Medicine, Rochester, New York, in 1976 and was an intern and resident at the University of Utah Medical Center from 1976 to 1979.

In 1979, he became a Diplomat of the American Board of Internal Medicine. He is president of Sierra Internal Medicine of Incline Village, established in 1981.

When several patients in Incline Village became ill with symptoms that resembled persistent mononucleosis, Daniel Peterson was one of the first physicians to recognize an outbreak of what is known as ME/Chronic Fatigue Syndrome (ME/CFS). He became a pioneering physician and researcher in understanding the biological characteristics and methods for diagnosing, managing and treating ME/CFS. He has also performed major studies of Ampligen as a treatment for ME/CFS, and studying the possible role of human herpes virus 6 (HHV-6) in CFS patients.

Dr. Peterson's experience as both a clinician and a research collaborator provides a unique perspective on CFS/ME for developing translational science.

Other Links

• Wikipedia - Dr Daniel Peterson

Liberty Hyde Bailey Professor, Department of Molecular Biology and Genetics, Cornell University, New York, USA

Maureen Hanson is Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics at Cornell University in Ithaca, NY. Previously she was on the faculty of the Department of Biology at the University of Virginia in Charlottesville and an NIH NRSA postdoctoral fellow at Harvard, where she also completed her Ph.D. degree. While most of her prior research has concerned cell and molecular biology in plant cells, she began a research program on ME/CFS after noting at a 2007 IACFS meeting the paucity of molecular biologists studying the illness. Her lab was part of the 2012 multicenter study organized by Ian Lipkin's group at Columbia University to assess the actual role of XMRV in ME/CFS. Dr. Hanson has a current project to examine the microbiome of ME/CFS patients and controls, in collaboration with Dr. Ruth Ley (Cornell Microbiology) and Susan Levine, M.D. (Manhattan, NY). Dr Levine is also collaborating with Dr. Hanson on an immune cell gene expression project that involves Dr. Fabien Campagne and Dr. Rita Shaknovich at Weill Cornell Medical School in New York City. Dr. Hanson's third project concerns analysis of blood samples from individuals performing a two-day cardiopulmonary exercise test at Ithaca College under the supervision of Dr. Betsy Keller.

Other Links

• Professor Maureen Hanson Cornell University Profile
• PMetabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism

Emeritus Professor of Clinical Virology, Department of Medical Sciences, Uppsala University, Sweden

Professor Jonas Blomberg is an MD and PhD, graduating at the University of Gothenburg. Has worked with Lipids at the department of Medical Biochemistry 1965-1972 as a Clinical Virologist in Gothenburg 1972-1979 and as a postDoc at John Stephensons Lab at NCI Frederick on retroviruses 1979-1981. He then worked as a Clinical Virologist in Lund, Sweden 1981-1995 and then as a professor of Clinical Virology in Uppsala 1996- to the present.

His main fields of interest are: Retrovirology, Bioinformatics, Clinical Virology and broadly targeted and multiplex methods for detection of microbial nucleic acid.

He also is interested in evolution and Infection biology.

Professor Blomberg is on the editorial board of Journal of Virology http://jvi.asm.org/site/misc/edboard.xhtml.

Other Links

• Professor Jonas Blomberg

Professor of Medicine at Georgetown University Medical Centre, washington, USA

James N. Baraniuk was born in Alberta, Canada, south of Banff. He earned his honours degree in chemistry and microbiology, medical degree, and unique bachelor's degree in medicine (cardiology) at the University of Manitoba, Winnipeg, Canada. Thereafter, he moved to Akron, OH, USA, for his internship and internal medicine residency at St Thomas Hospital. After another year of internal medicine residency at Duke University Medical Center, Durham, NC, he trained with Dr C.E. Buckley, III, in allergy and clinical immunology. He moved to the laboratory of Dr Michael Kaliner at the National Institute of Allergy and Infectious Diseases, Bethesda, MD, and there began his long-standing collaboration with Dr Kimihiro Ohkubo. After 2 years studying neuropeptides, he joined Dr Peter Barnes' laboratory at the National Heart and Lung Institute, Brompton Hospital, London, UK. Dr Baraniuk returned to Washington, DC, and Georgetown University, where he is currently Associate Professor with Tenure in the Department of Medicine.

Other Links

• Professor James Baraniuk

Professor of Biochemistry and Genetics at the Stanford School of Medicine in Stanford, California, USA

Ronald W. Davis, Ph.D., is a Professor of Biochemistry and Genetics at the Stanford School of Medicine in Stanford, California.

He is a world leader in the development of biotechnology, especially the development of recombinant DNA and genomic methodologies and their application to biological systems.

At Stanford University, where he is Director of the Stanford Genome Technology Center, Dr. Davis focuses on the interface of nano-fabricated solid state devices and biological systems.

He and his research team also develop novel technologies for the genetic, genomic, and molecular analysis of a wide range of model organisms as well as humans.

The team's focus on practical application of these technologies is setting the standard for clinical genomics.

Other Links

• Stanford Genome Technology Center
• Ron Davis named one of today's greatest inventors
• The Chronic Fatigue Syndrome Research Center (CFSRC)

Professor for Immunology and Deputy Chair Institute of Medical Immunology Berlin Charite, Germany

Head of the Outpatient Clinic for Adult Immunodeficiency. Clinical Training in Hematology and Oncology.
Research interest in CFS/ME, Immunodeficiency, Cancer Immunology.

Other Links

• ResearchGate
• Charité – Universitätsmedizin Berlin
• Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome

Professor of Biochemistry and Genetics at the Stanford School of Medicine in Stanford, California, USA

Ronald W. Davis, Ph.D., is a Professor of Biochemistry and Genetics at the Stanford School of Medicine in Stanford, California.

He is a world leader in the development of biotechnology, especially the development of recombinant DNA and genomic methodologies and their application to biological systems.

At Stanford University, where he is Director of the Stanford Genome Technology Center, Dr. Davis focuses on the interface of nano-fabricated solid state devices and biological systems.

He and his research team also develop novel technologies for the genetic, genomic, and molecular analysis of a wide range of model organisms as well as humans.

The team's focus on practical application of these technologies is setting the standard for clinical genomics.

Other Links

• Stanford Genome Technology Center
• Ron Davis named one of today's greatest inventors
• The Chronic Fatigue Syndrome Research Center (CFSRC)

Chief of the Department of Pulmonary Medicine, Tampere University Hospital, Finland

Other Links

• ResearchGate

Professor Elisa Oltra is a professor of Cell and Molecular Biology at the Universidad Católica de Valencia “San Vicente Mártir”, Spain, where she also works as a researcher in the area of stem-cell and cancer

Dr. Elisa Oltra is a professor of Cell and Molecular Biology at the Universidad Católica de Valencia “San Vicente Mártir” where she also works as a researcher in the area of stem-cell and cancer.

She obtained an M.S. degree in Biochemistry at the Universidad de Valencia (Spain) and later earned her PhD in Biochemistry, Cell and Molecular Biology at the University of Miami, FL (USA) where she stayed for her post-doctoral training and later, as Senior Scientist till 2006 when she moved back to Spain.

During her studies at the University of Miami she identified alternative 5´UTR sequences involved in regulating cell-cell communication through mechanisms of differential connexin43 expression in the heart.

She also isolated a novel essential protein (Ini) and demonstrated its participation in mechanisms of transcription and splicing.

In 2009 she started a project to investigate the molecular basis of Fibromyalgia having identified at present irregularities in RNAseL expression and miRNAs profile changes in the participating patients which could lead to a deeper understanding of the disease.

In 2012 she joined the IVP Valencian Institute of Pathology, also at the Universidad Católica de Valencia where she is currently studying a specific type of vesicles: the exosomes, as mediators of stem-cell based therapies.

She is also academic director of the first officially accredited Master degree in Biobanking in Europe in collaboration with the Spanish Network of Biobanking at the Instituto de Salud Carlos III, Madrid (Spain). From https://publons.com/author/361418/elisa-oltra#profile

Other Links

• ResearchGate

Professor of Infection and Immunity & Director at Biomedical Research Centre at University of East Anglia, Norfolk, UK

Professor Wileman is Professor of Infection and Immunity & Director and Director at Biomedical Research Centre at Univ. of East Anglia.

He was Head of Dep. Immunology and Pathology and Virus Cell Biology Group at Institute of Animal Health; Assistant Professor at Dep. Medicine at Harvard Medical School and Claudia Adam's Barr Investigator in Cancer Research, Dept. Molecular Immunology, Dana Farber Cancer Institute, Harvard Medical School; Fellow of the Parker Francis Pulmonary Research Foundation, Dept.Cell Biology, Washington Univ. Medical School.

Other Links

• UEA

Program Director in the National Institute of Neurological Disorders and Stroke at the National Institutes of Health in the United States.

Dr. Whittemore is a Program Director in the Synapses, Channels and Neural Circuits Cluster. Her interest is in understanding the underlying mechanisms of the epilepsies including the study of genetic and animal models of the epilepsies.

The major goal is to identify effective treatments for the epilepsies and to develop preventions. Dr. Whittemore received a Ph.D. in anatomy from the University of Minnesota, followed by post-doctoral work at the University of California, Irvine, and a Fogarty Fellowship at the Karolinska Institute in Stockholm, Sweden.

She was on the faculty of the University of Miami School of Medicine in The Miami Project to Cure Paralysis prior to working with several non-profit organizations including the Tuberous Sclerosis Alliance, Genetic Alliance, Citizens United for Research in Epilepsy (CURE), and the National Coalition for Health Professional Education in Genetics (NCHPEG).

She also just completed a four-year term on the National Advisory Neurological Disorders and Stroke Council.

Other Links

• ResearchGate

Professor of Infection and Immunity & Director at Biomedical Research Centre at University of East Anglia, Norfolk, UK

Professor Wileman is Professor of Infection and Immunity & Director and Director at Biomedical Research Centre at Univ. of East Anglia.

He was Head of Dep. Immunology and Pathology and Virus Cell Biology Group at Institute of Animal Health; Assistant Professor at Dep. Medicine at Harvard Medical School and Claudia Adam's Barr Investigator in Cancer Research, Dept. Molecular Immunology, Dana Farber Cancer Institute, Harvard Medical School; Fellow of the Parker Francis Pulmonary Research Foundation, Dept.Cell Biology, Washington Univ. Medical School.

Other Links

• UEA

Leader of the Irsi Caixa (Institute for AIDS Research) Research Institute's Cell Virology and Immunology Research Group, Barcelona, Spain ,

The IrsiCaixa Institute for AIDS Research IRSI Caixa works alongside the most prestigious international research centres, and its publications are among those with the most impact in their field.

Dr Blanco has vast experience in HIV related research but has also been involved in ME/CFS research as in 2013 his group published the paper , Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome, Curriu et al. Journal of Translational Medicine 2013, 11:68.

Other Links

• IrsiCaixa
• Journal of Translational Medicine

M.D./Ph.D. student, Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Jakob Theorell started his medical training at Karolinska Institutet in 2007.
He is currently enrolled in the MD-PhD Program at Karolinska Institutet.
He works in the Yenan Bryceson Group
in Karolinska Institutet in Stockholm.
His work focuses on understanding the mechanisms of disease in patients suffering from chronic immunodeficiency syndromes.

The Yenan Bryceson Group is based at the Center for Infectious Medicine and employs a wide range of techniques including multiparameter flow cytometry, confocal microscopy, live-cell imaging, next-generation sequencing, and biochemical techniques. To gain clinical and scientific insights into human diseases, we collaborate closely with clinicians at Karolinska Institutet, across Scandinavia and the rest of the world.

Other Links

• ResearchGate
• Yenan Bryceson group

Director, Institute for Neuro Immune Medicine, Nova Southeastern University
Director, Clinical Immunology Research, Miami VAMC
Professor of Medicine, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University
Chair, Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University
Professor Emerita, University of Miami, School of Medicine

Nancy Klimas, MD, has more than 30 years of professional experience and has achieved international recognition for her research and clinical efforts in multi-symptom disorders, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI), Fibromyalgia, and other Neuro Immune Disorders. She is immediate past president of the International Association for CFS and ME (IACFS/ME), a professional organization of clinicians and investigators, and is also a member of the VA Research Advisory Committee for GWI, the NIH P2P CFS Committee, and the Institute of Medicine ME/CFS Review Panel. Dr. Klimas has advised three Secretaries of Health and Human Services, including Kathleen Sabelius, during her repeated service on the Health and Human Services CFS Advisory Committee. Dr. Klimas has been featured on Good Morning America, in USA Today and the New York Times.

Other Links

• INSTITUTE FOR NEURO IMMUNE MEDICINE

Other Links

• ResearchGate

Chief of Chronic Viral Diseases Branch, National Center for Emerging and Zoonotic Infectious Diseases, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention

Elizabeth (Beth) Unger, PhD, MD, received an undergraduate degree in Chemistry at Lebanon Valley College, Annville, PA. She then earned her PhD and MD in the Division of Biologic Sciences at the University of Chicago where she also began a residency in pathology. Her residency and fellowship was completed at Pennsylvania State University Medical Center. During this time, Dr. Unger developed a practical method of colorimetic in situ hybridization. This work led to interest in tissue localization of HPV and ultimately to her initial appointment to CDC in 1997 to pursue molecular pathology of HPV and CFS.

Dr. Unger has served as the Acting Chief of CVDB since January 2010 and has 13 years of experience in CVDB, where she has participated in the design and implementation of CFS research and HPV laboratory diagnostics. During this time, she was co-author on 25 peer-reviewed manuscripts related to CFS, including the often-cited descriptions of the Wichita and Georgia population-based studies. In addition, Dr. Unger has been instrumental in efforts by WHO to establish an HPV LabNet and serves as lead of a WHO HPV Global Reference Laboratory. She is co-author of 142 peer-reviewed publications and 24 book chapters and serves on the editorial board of six scientific journals. In 2008, for her HPV research accomplishments, she received the Health and Human Services (HHS) Career Achievement Award.

Dr Unger has been selected to serve as the Chief of the Chronic Viral Diseases Branch (CVDB) in the Division of High-Consequence Pathogens and Pathology (DHCPP), National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC).

Specialist in Rehabilitation Medicine, Stora Sköndal, Stockholm, Sweden

Dr. Per Julin is a specialist in rehabilitation medicine at the Stora Sköndal clinic in Stockholm, Sweden and also Senior Consultant, Neurological Rehabilitation Medicine at Karolinska Institute, Department of Clinical Sciences, Danderyd Hospital Stockholm, Sweden.

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Other Links

• 27 januari 2016 av AllmänMedicin
• RME-konferens - Neuroradiologiska studier vid ME/CFS

Professor of Genetic Epidemiology and Professor of Chronic Illness, Norwich Medical School, Norwich, UK
Consultant Rheumatology Norfolk and Norwich University Hospital, Norwich, UK

Professor Alexander MacGregor is a clinical epidemiologist, has expertise in genetic epidemiology (linking with the Twins UK cohort) and orthopaedic outcomes research thorough involvement with the national joint register.

Other Links

• ResearchGate

Professor of Tumour Virology (Biochemistry), University of Sussex , Sussex, UK

Following her PhD, Dr West worked on the the c-myc transcription factor at the University of Leicester as a Post-doctoral Fellow before moving to the MRC Laboratory of Molecular Biology at Cambridge to work on the regulation of HIV transcription. She moved to Sussex in November 2001 as an independent Wellcome Trust Fellow and was appointed as a member of academic faculty in March 2006, part-funded by the Wellcome Trust until March 2010.

Research expertise:
B cells, Cancer cell biology, Cell cycle, Chromatin, Epigenetics, Transcriptional regulation, Translational regulation, Virology

Other Links

• Sussex Scientists Receive Grant for Blood Cancer Research

Professor Institute for Biomedicine , Tronstad Lab, Bergen, Norway

Prof. Tronstad completed his graduate studies in biochemistry at the University of Bergen (UiB) in 2002. As postdoc at the Haukeland University Hospital, he studied bioactive compounds with the potential to modulate mitochondrial functions in cancer cells. In 2005 he was recruited to the Department of Biomedicine, UiB, where he started his research group to investigate metabolism and mitochondrial physiology. His laboratory seeks to better our understanding of how defective mitochondrial homeostasis may disturb cell physiology, and how this may be involved in mechanisms of cancer and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Karl was involved with the recent paper to come from Bergen - Journal of Clinical Investigation Insight. The Tronstad Lab investigates cell metabolism and mitochondrial biology and we are very fortunate that he can spare time to participate in the Colloquium.

Specialisms:
Metabolism, Cell biology, Mitochondria, Biochemistry

Other Links

• ResearchGate

Research Associate , Department of Molecular Biology and Genetics, Cornell University, New York, USA

Research Associate at Department of Molecular Biology and Genetics at Cornell

Other Links

• http://www.news.cornell.edu/stories/2016/06/indicator-chronic-fatigue-syndrome-found-gut-bacteria
• Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism
• ResearchGate
• Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome

Leader of the Labour Party, UK

Jeremy Bernard Corbyn is a British politician serving as Leader of the Labour Party and Leader of the Opposition since 2015.
He has been the Member of Parliament (MP) for Islington North since 1983.

Links

• Wikipedia

Links

• www.autismfreebrain.org
• www.mastcellmaster.com
• www.brain-gate.org
• http://sackler.tufts.edu/Faculty-and-Research/Faculty-Profiles/Theoharis-Theoharides-Profile
• http://sackler.tufts.edu/Faculty-and-Research/Faculty-Research-Pages/Theoharis-Theoharides

Professor of Pharmacology and Internal Medicine, Tufts University, Boston, USA

Theoharis Theoharides is Professor of Pharmacology and Internal Medicine, as well as Director of Molecular Immunopharmacology and Drug Discovery, in the Department of Immunology at Tufts University School of Medicine, Boston, MA.
He was born in Thessaloniki, Greece, and graduated with Honors from Anatolia College. He received all his degrees with Honors from Yale University, and was awarded the Dean’s Research Award and the Winternitz Prize in Pathology.

He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award “recognizing excellence, compassion and service.” He also received a Certificate in Global Leadership from the Tufts Fletcher School of Law and Diplomacy and a Fellowship at the Harvard Kennedy School of Government. He has been serving as the Clinical Pharmacologist of the Massachusetts Drug Formulary Commission continuously since 1986. In Greece, he has served on the Supreme Advisory Health Councils of the Ministries of Health and of Social Welfare, as well as on the Board of Directors of the Institute of Pharmaceutical Research and Technology, and he is a member of the International Advisory Committee for the University of Cyprus School of Medicine. He first showed that mast cells, known for causing allergic reactions, are critical for inflammation, especially in the brain, and are involved in a number of inflammatory conditions that worsen by stress such as allergies, asthma, chronic fatigue syndrome, eczema, fibromyalgia, migraines, mastocytosis, multiple sclerosis, psoriasis, and most recently autism spectrum disorder.

He has also shown that corticotropin-releasing hormone (CRH), neurotensin and substance P, peptides secreted under stress, act together, and with the cytokine IL-33, to trigger mast cells and microglia to secrete inflammatory molecules. These processes are inhibited by the novel flavonoids, luteolin and tetramethoxyluteolin that he has helped formulate in unique dietary supplements and a skin lotion. He has published over 400 scientific papers (JBC, JACI, JPET, NEJM, Nature, PNAS, Science) and 3 textbooks with 29,887 citations (h-factor 84) and he is in the top 5% of authors most cited in pharmacological and immunological journals. He has received 37 patents and trademarks, including three patents covering the use of luteolin in brain inflammation and autism: US 8,268,365 (09/18/12); US 9,050,275 (06/09/15); US 9,176,146 (11/03/15).

Acting as Advisor, he was instrumental in the development of ibuprofen (Upjohn), Cetirizine (UCB) and Niaspan (Kos). He is also the Scientific Director of Algonot, LLC, as well as President of Theta Biomedical Consulting and Development Co., Inc., of BiomedAdvice, LLC, and of the nonprofit Brain-Gain.org. He is a member of 15 academies and scientific societies. He was inducted into the Alpha Omega Alpha National Medical Honor Society and the Rare Diseases Hall of Fame. At Tufts, he served on the Curriculum, Students Promotion, Grievance, Faculty Promotion and Tenure, as well as Strategic Planning Committees. He received the Tufts Excellence in Teaching ten times, the Tufts Distinguished Faculty Recognition Award twice, the Tufts Alumni Award for Faculty Excellence, Boston Mayor’s Community Award, and the Dr. George Papanicolau Award, as well as Honorary Doctor of Medicine from Athens University and Honorary Doctor of Sciences from Hellenic-American University. He is “Archon” of the Ecumenical Patriarchate of Constantinople.

University Hospital of North Norway, Harstad, Norway - Internal Medicine

Dr Johnsen works in the medical department at the University of Northern Norway in Harstad.
He is currently involved in the clinical trial of FMT which is being funded by the Norwegian Health Council. Five million Norwegian kroner has been awarded for the trial.

The study is supported by Norwegian Research Council. Together, it will be included 78 participants who either receive treatment with FMT from a healthy donor or placebo.
The study is double blinded, which means that neither participants nor scientists will know who received the treatment from donor or placebo before the study ends.
Startup with the inclusion of participants begins during Summer 2018.

Links

• Forskningsjubel for Tarmprosjekt for ME-syke
• Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial
• Researchgate
• The Arctic University of Norway

NIH National Institute of Neurological Disorders, Bethesda, Maryland, USA

Dr. Nath received his MD degree from Christian Medical College in India in 1981 and completed a residency in Neurology from University of Texas Health Science Center in Houston, followed by a fellowship in Multiple Sclerosis and Neurovirology at the same institution and then a fellowship in Neuro-AIDS at NINDS.

He held faculty positions at the University of Manitoba (1990-97) and the University of Kentucky (1997-02).

In 2002, he joined Johns Hopkins University as Professor of Neurology and Director of the Division of Neuroimmunology and Neurological Infections.

He joined NIH in 2011 as the Clinical Director of NINDS, the Director of the Translational Neuroscience Center and Chief of the Section of Infections of the Nervous System.

His research focuses on understanding the pathophysiology of retroviral infections of the nervous system and the development of new diagnostic and therapeutic approaches for these diseases.

Links

• • Nath A. Neuroinfectious diseases: a crisis in neurology and a call for action. JAMA Neurol. 2015;72(2):143-4.
  
  
  • Uzasci L, Auh S, Cotter RJ, Nath A. Mass spectrometric phosphoproteome analysis of HIV-infected brain reveals novel phosphorylation sites and differential phosphorylation patterns. Proteomics Clin Appl. 2016;10(2):126-35.
  
  
  • Li GH, Anderson C, Jaeger L, Do T, Major EO, Nath A. Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4. AIDS. 2015;29(7):755-66.
  
  
  • Johnson TP, Patel K, Johnson KR, Maric D, Calabresi PA, Hasbun R, Nath A. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Proc Natl Acad Sci U S A. 2013;110(33):13588-93.
  
  
  • Douville RN, Nath A. Human endogenous retroviruses and the nervous system. Handb Clin Neurol. 2014;123:465-85.

University of Helsinki, Finland

Prof Markku Partinen is a neurologist and an internationally well-known opinion leader and expert in sleep research and sleep medicine.

Professor Markku Partinen is currently Director of the Helsinki Sleep Clinic, Vitalmed Research Centre, and Principal Investigator of Sleep Research at Institute of Clinical Medicine, Clinicum, University of Helsinki, Finland.

He has been the coordinator of the NARPANord Narcolepsy Consortium.
He became interested in sleep research while studying medicine at the University of Montpellier, France.
He obtained his medical degree (DrMed) from Montpellier in 1976 (Supervisor Prof Pierre Passouant).
He received his PhD in 1982 (epidemiology of sleep disorders), and degree of a specialist in neurology in 1982, in Helsinki, Finland.
He has worked as a postdoc researcher at Stanford University, USA in 1985-86 and in Bologna, Italy in 1987.
In addition, he has had several shorter visits as visiting researcher or visiting Professor at different Universities in Europe.
His main interests in sleep medicine have been narcolepsy, excessive daytime sleepiness and fatigue (including ME), sleep apnea, and parasomnias.
He has published more than 330 original articles in peer reviewed Journals in addition to writing many book Chapters and editing several books.
His Hirsch factor (H-factor) is 59 in ISI Web of Sciences and 64 in Scopus.
He has served in the Editorial Boards and as Assistant Editor in Sleep, Journal of Sleep Research and Sleep Medicine.
He has had many International positions in different research societies including Member of the Scientific Board and Vice-President of the European Sleep Research Society (ESRS), President of the Scandinavian Sleep Research Society, President Elect and President of the World Association of Sleep Medicine (WASM), Coordinating Secretary of the World Federation of Sleep Research Societies (WFSRS) and President and Member of the Board of the Scandinavian Sleep Research Society.
He has been President of the ESRS congress in 1992 (Helsinki), the World Congress of Sleep Apnea in 2003 (Helsinki), and the WASM congress in 2007 (Bangkok).
In addition, he has organized several smaller meetings and symposia in the field of narcolepsy, RBD and different sleep disorders.
Currently he is a Member of the Board in the ESRS EU-Narcolepsy Network (EU-NN) and Chair of Scientific Board of the EU-NN, President of the Finnish Parkinson Association and President of the Finnish Sleep Research Society.
He has published more than 250 articles in peer-reviewed international journals, several books and chapters.

Links

• European Sleep Research Society


• Researchgate Markku Partinen


• Research at the University of Helsinki

Links

• Study suggests enterovirus infections linked with autoimmunity that leads to type 1 diabetes


• Researchgate Professor Heikki Hyöty


• Investigator Spotlight

School of Medicine, Virology University of Tampere, Finland.

Professor Heikki Hyöty is a professor of Virology at the University of Tampere, Finland

Professor Heikki Hyöty’s group has long experience in studies evaluating the role of viruses in type 1 diabetes and allergies.
He has published pioneering prospective studies and has made many new discoveries on the role of enteroviruses in diabetes.
One recent initiative is a project aiming at developing enterovirus vaccine against type 1 diabetes.
This long-term commitment to this particular topic has created a strong research center in Tampere.
Dr. Hyöty has previous experience from the coordination of large scale international research projects (for example two EU projects) and the laboratory participates in international quality control programmes (e.g Quality Control for Molecular Diagnostics, QCMD) and complies with general GLP and written SOPs.
Professor Hyöty’s group has also made pioneering work in translation of research findings in collaboration with academic and industrial partners.

Research Director, Coordinating Research Centre, Bispebjerg and Frederiksberg Hospital, Denmark

Expertises

Autonomic nervous system; Heart rate and blood pressure control; Cardiovascular physiology and pathophysiology;

HPV vaccines and -complications

Main research areas

Methods for the study of autonomic cardiovascular control; Mathematical modelling of cardiovascular control; Autoimmune response to vaccination; Mathematical modeling of the neuroinflammatory reflex

Current research

Mathematical analysis of hemodynamic adaptations to the upright posture.

Mathematical analysis of hemodynamic response to Valsalva manoeuvre

Dynamic T-wave alterations and the autonomic nervous system

Mathematical analysis of cytokine response to LPS in humans

Autoimmunity in patients with possible side effects to HPV vaccination

Links

• Researchgate Jesper Mehlsen


• Postural Orthostatic Tachycardia Syndrome (POTS) in Denmark: Increasingly recognized or new epidemic?

School of Biological Sciences, UEA, UK

Senior Lecturer in Pharmacology

Links

• Researchgate Dr Samuel Fountain

Links

• Researchgate Naomi Allen


• Dr Naomi Allen, University of Oxford


• Cancer - Dr Naomi Allen, UK Biobank

Senior Epidemiologist, UK Biobank, University of Oxford, UK

Senior Epidemiologist, UK Biobank

Naomi Allen is Senior Epidemiologist for UK Biobank and an Associate Professor of Epidemiology at the University of Oxford, UK.

She is responsible for processing the linkage of routine electronic medical records into the study for long-term follow-up (including deaths, cancers, primary and secondary care data as well as other health-related datasets).

She helps to co-ordinate the introduction of new enhancements into the resource (such as the development of web-based questionnaires and proposals for cohort-wide biomarker assays) and provides scientific advice to researchers worldwide wishing to access UK Biobank.

Her academic research interests are in cancer epidemiology, with a keen research interest in the role of diet, obesity and circulating biomarkers in cancer development.

Links

• Researchgate Lesley Hoyles


• The link between the gut microbiome and the blood-brain barrier

Imperial College, London, UK

Dr Lesley Hoyles is a microbiologist and computational biologist, and an MRC Intermediate Research Fellow in Data Science (UK Med-Bio). The early years of her career focussed on the isolation and phenotypic characterization of novel anaerobic Actinobacteria. Her PhD studies at the University of Reading introduced Dr Hoyles to the gut microbiota, and led her to develop an interest in integrating various -omics and traditional approaches to look at microbe–host interactions and co-metabolism. After completing a Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology (IRCSET scheme) at University College Cork to develop improved methods for the isolation and characterization of gut-associated bacteriophages, Dr Hoyles was awarded an MRC Advanced Scholarship to undertake an MSc in Bioinformatics with Theoretical Systems Biology at Imperial College London.

Subsequently, Dr Hoyles has worked in the field of translational systems biology at Imperial College London, using her unique skill set to investigate host–microbiome interactions and co-metabolism in humans, and animal and in vitro models.

In addition to her research interests, Dr Hoyles teaches on the MRes Biomedical Research stream Microbiome in Health and Disease. She is heavily involved in outreach activities, running Bugs In Your Guts and an after-school science club, and volunteering at the Turing House CoderDojo. Dr Hoyles is a STEM Ambassador and an Academic Editor for PeerJ.

University of Oxford, UK

Dr Karl Morten is a researcher and laboratory manager at Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University.

Links

• Researchgate Karl J Morten

Haukeland University Hospital, Bergen, Norway

Professor Kristian Sommerfelt is a paediatric neurologist at Haukeland University hospital in Bergen, Norway

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Links

• Kristian Sommerfelt snakker om utredning, oppfølging og prognose for barn og unge med ME


• Researchgate Kristian Sommerfelt

University of Oslo, Norway

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Links

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Quadram Institute Bioscience, UK

PhD Students at Quadram Institute Bioscience are Daniel Vipond, Fiona Newberry, Katahrine Seton and Shen-Yuan Hsieh.

Projects funded by Invest in ME Research are here - http://www.investinme.org/ce-projoverview.shtml

Links

• Research Blog


• Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

Links

• Immune tolerance Immune regulation


• Benedict Seddon

Benedict Seddon, Institute of Immunity and Transplantation · Division of Infection and Immunity, UCL, London, UK

Dr Ben Seddon undertook his PhD with Prof Don Mason at the former MRC's Cellular Immunology Unit, at the Sir William Dunn School of Pathology in Oxford University.
There he studied the role and mechanisms of regulatory T cells in the control of autoimmunity in rats.
He then moved to the MRCs National Institute for Medical Research where he worked first as a post-doc with Dr Rose Zamoyska in the Division of Molecular Immunology, and then started his independent research group as a Programme Leader in the Division of Immune Cell Biology. He has had 10 years at NIMR establishing a research programme investigating the mechanisms of T cell homeostasis, generating novel genetic models of TCR and cytokine signalling, employing mathematical approaches to gain systems level understanding and identifying novel roles for inflammatory signalling for T cell maturation.

In 2013, he relocated the lab to the Institute of Immunity and Transplantation at the Royal Free Hospital Campus of University College London, where he is investigating the role of TNFSFR signalling and NF-kappaB transcription factors in the maturation and function of T cells in health and disease.

UCL, London, UK

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Links

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Assistant Professor at Nova Southeastern University

EDUCATION/TRAINING:
B.S.- Pharmacy - North Gujarat University
M.S.-Pharmacology - Northeastern University
Ph.D.- Pharmacology - Northeastern University

Links

• Researchgate Malav Trivedi

Links

• Researchgate Anne Cooke


• Wellcome-MRC Cambridge Stem Cell Institute

Emeritus Professor of Immunobiology Anne Cooke, University of Cambridge, UK

Anne Cooke began her academic career as a postdoctoral fellow. From 1970 to 1972, she held a SRC postdoctoral fellowship in the Department of Biochemistry at the University of Sussex. From 1972 to 1973, she was a postdoctoral fellow at the University of Illinois and worked at the Medical Center, Chicago, USA. From 1973 to 1978, she held a Arthritis Research UK postdoctoral research fellowship in the Immunology Department of Middlesex Hospital. Then from 1978 to 1981, while remaining at Middlesex Hospital, she was a Wellcome Trust senior research fellow.

In 1981, she moved from research into teaching and research. From 1981 to 1988, she was a Wellcome Trust senior lecturer within the immunology division of the UCL Medical School and also at the Middlesex Hospital Medical School. From 1988 to 1990, she was Reader in Experimental Immunology at University College London.

In 1990, Anne moved to the University of Cambridge. From 1990 to 1996, she was a lecturer in the Department of Pathology. In 1992, she was elected a Fellow of King's College, Cambridge. From 1996 to 2000, she was Reader in Immunology. In 1999, she was a visiting professor at the University of Washington, Seattle. On 1 October 2000, she was granted a personal chair and appointed Professor of Immunobiology. In 2013, she retired from full-time academia; she was appointed Professor Emeritus and made an Emeritus Fellow of King's College.

From https://en.wikipedia.org/wiki/Anne_Cooke

BSc (Hons) Biochemistry, University of Glasgow
DPhil Biochemistry, University of Sussex.
SRC Postdoctoral Fellowship, Dept Biochemistry, U. Sussex.
Postdoctoral Fellow, University of Illinois at the Medical Center, Chicago,USA.
ARC Postdoctoral Research Fellowship, Immunology Department, Middlesex Hospital Medical School.
Honorary Lecturer, Dept Biochemistry, St Mary's Hospital Medical School.
Wellcome Trust Senior Research Fellow, Immunology Department, Middlesex Hospital Medical School.
Wellcome Trust Senior Lecturer, Immunology Division, University College and Middlesex Schools of Medicine.
Reader in Experimental Immunology University College, London
Lecturer, Department of Pathology, University of Cambridge.
Reader in Immunology, Department of Pathology, University of Cambridge.
Professor of Immunobiology, Department of Pathology, University of Cambridge.
Honorary Fellow, University College, London.
Fellow of the Academy of Medical Sciences
Honorary Degree University of Copenhagen

The Great Hall

On the first floor of this Westminster venue is the most impressive and largest function space within the building. The Great Hall a conference room of over 370 square meters and over 13 meters in height is adorned with marbled columned walls, ornate gold leaf and embellished plaster. An oak floor complements a stunning painted ceiling and two large crystal chandeliers at either end of the event room. There are seven floor-to-ceiling windows along the West wall letting in a lot of natural daylight and allowing for passers-by to gaze up and marvel at the magnificent ceiling and chandeliers.

The room was conceived as part of the building’s initial plans in 1904. The Civil Engineers wanted to create a large hall similar to the grand meeting rooms found at the Inns of Court in the City and to be comparable to impressive rooms such as Lincoln’s Inn. The painted ceiling and chandeliers were donated by a former president of the Institution of Civil Engineers as a reminder of the role the Institution and its members played during the First World War.

Many notable and historic special events take place in the Great Hall these include: the signing of the charter establishing UNESCO (United Nations Educational, Scientific and Cultural Organization) in 1945 and His Royal Highness the Duke of Edinburgh sat in the room to take his Royal Navy examinations. Feature films including, Bridget Jones: Edge of Reason in 2004 and Starter for 10 in 2006 filmed scenes within the four walls. More recently the Great Hall has been used as a communications room for international journalists when the venue housed the London Media Centre for the 2012 Olympic and Paralympic Games. By way of providing a unique backdrop during recent London fashion weeks the following fashion houses showcased their seasonal collections here; L’Wren Scott 2013, Alice Temperly 2012, and Antonio Berardi 2010.

Other Links

• One Great Biomedical Research Conference

CFS Research Coodinator

Dr Eliana Lacerda MD MSc PhD

London School of Hygiene and Tropical Medicine http://www.zoominfo.com/p/Eliana-Lacerda/699365244

Other Links

• Eliana Lacerda LSHTM

Professor of Immunology, LSHTM, UK

Professor Eleanor Riley BSc BVSc PhD FSB FMedSci

Eleanor Riley graduated from Bristol University with degrees in Cellular Pathology and Veterinary Science. After an internship in Veterinary Pathology at Cornell University (USA) she studied for a PhD in immunology and parasitology in the Department of Veterinary Pathology at the University of Liverpool. She began working on the immunology of malaria in 1985, as a member of the senior scientific staff at the Medical Research Council Laboratories in The Gambia, West Africa. In 1990, Eleanor moved to the University of Edinburgh as a Wellcome Trust Senior Research Fellow. Eleanor moved to the London School of Hygiene and Tropical Medicine in October 1998 where she is Professor of Infectious Disease Immunology. Eleanor is currently Chair of the BBSRC Bioscience for Health Strategy Advisory Panel and Deputy Chair of the MRC Infections and Immunity Board.

Other Links

• EUROPEAN VIRTUAL INSTITUTE OF MALARIA RESEARCH
• Academy of Medical Sciences

Programme Leader, MRC Mitochondrial Biology Unit, Cambridge

Dr Mike Murphy

EDUCATION & EMPLOYMENT

1980-1984 BA in Chemistry, first class honours, first in class, Trinity College, Dublin, Ireland

1984-1987 PhD, Department of Biochemistry, University of Cambridge, UK

1988 Associate Research Scientist, Columbia University College of Physicians and Surgeons, New York

1989 Teacher with Voluntary Services Overseas (London) in Zimbabwe

1990-1992 Lecturer, Biochemistry Department, Trinity College, Dublin, Ireland

1992-2001 Lecturer/Senior Lecturer/Associate Professor, Biochemistry Department, University of Otago, New Zealand

1999 Sabbatical Visitor, Biozentrum, University of Basel, Switzerland

1999 Sabbatical Visitor, University of Alabama at Birmingham, USA

2000-2001 Associate Dean for Research, Otago School of Medical Sciences

2001-present Programme Leader, MRC Mitochondrial Biology Unit, Cambridge, UK AWARDS & HONOURS 1982 C Walter Jones Prize in Organic Chemistry

1982-1987 Foundation Scholarship

1984 Cocker Medal for Experimental Chemistry

1984-1987 Open Research Studentship, Peterhouse, University of Cambridge

2000 Applied Biosystems Medal, NZ Society of Biochemistry and Molecular Biology

2000 Research Medal of the New Zealand Association of Scientists

2001-present Honorary Fellow, Depts of Chemistry and Biochemistry, University of Otago

2008 The Nathan O. Kaplan Lecturer, University of California, San Diego

2012 Honorary Fellow of the Royal Society of New Zealand (Hon FRSNZ)

2016 Keilin Memorial Lecture and Medal EDITORIAL BOARDS

2003-present Biochemical Journal: Deputy chair (2007-), Editorial board (2003-)

1999-2014 Archives of Biochemistry and Biophysics: Editorial board

2009-2011 Current Opinion in Investigational New Drugs: Editorial board

2012-present Free Radical Biology and Medicine: Editorial board

2002-present FEBS Journal: Editorial advisory panel

2013-present Redox Biology: Editorial board

2013-present Redox Report: Editorial board

2010-present Free Radical Research: Editorial board

2003–2007 Biochemical Society Theme Panel III (Bioenergetics and Metabolism)

2001-present Scientific Advisory Board, Antipodean Pharmaceuticals, Auckland and San Francisco

2010-2013 Telethon Italy, Scientific Committee

2009-2011 Buck Institute for Aging Research, external advisory board for the U54 Interdisciplinary Research Center

PATENTS

Mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J. Smith, United States Patent US 6,331,532.

Mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J. Smith, United States Patent US 6,984,636.

Mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J. Smith, Australian Patent AU 763179.

Mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J. Smith, New Zealand Patent NZ 505352.

Mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J. Smith, United States Patent US 7,109,189.

Mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J. Smith, New Zealand Patent NZ 538371.

Triphenylphosphonium thionitrite nitric oxide donors, Michael P. Murphy and Robin A. J. Smith European Patent EP2066680.

Triphenylphosphonium thionitrite nitric oxide donors, Michael P. Murphy and Robin A. J. Smith. Canadian Patent CA 2664744.

Triphenylphosphonium thionitrite nitric oxide donors, Michael P. Murphy and Robin A. J. Smith. United States Patent US 12/732,909.

Mitoquinone derivatives used as mitochondrially targeted antioxidants, Michael P. Murphy and Robin A. J Smith, United States patent US 7,888,334.

Mitochondrially targeted antioxidants, Michael P Murphy and Robin A. J Smith, Canadian Patent CA 2311318

Other Links

• Dr Mike Murphy
• WHAT ARE MITOCHONDRIA?
• Cambridge Cardiovascular

Research Assistant; Inflammation; Div of Medicine; Faculty of Medical Sciences, UCL, UK

Fane Mensah

Other Links

• ResearcGate

Assistant professor of Psychology, Computer Science and Medicine, Institute for Neuro Immune Medicine, Nova Southeastern University, Miami, USA

Dr Travis Craddock

Travis Craddock, Ph.D. is an assistant professor of Psychology, Computer Science and Medicine applying systems biology and biophysics methods towards the purpose of identifying novel treatments for complex chronic illness involving neuroinflammation. His postdoctoral work was conducted under the supervision of Gordon Broderick, Ph.D., in the Broderick Laboratory for Clinical Systems Biology in the Department of Medicine, Faculty of Medicine and Dentistry at the University of Alberta. His work with Gordon Broderick, Ph.D., focused on using a theory driven systems biology approach to investigate neuroendocrine-immune interaction dynamics in neuroinflammation and its relation complex diseases such as Gulf War Illness, and chronic fatigue syndrome. This work was funded by the U.S. Department of Defense.

He received his BSc. in co-op physics from the University of Guelph and went on to finish a M.Sc. and Ph.D. in the field of biophysics at the University of Alberta under the supervision of Jack Tuszynski, Ph.D. His graduate research activities focused on subneural biomolecular information processing, and nanoscale neuroscience descriptions of memory, consciousness and cognitive dysfunction in neurodegenerative disorders such as Alzheimer’s disease.

Other Links

• Travis Craddock - Google Scholar Citations

Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia

Dr Chris Armstrong

Other Links

• Chris Armstrong Research Profile
• PUBLICATIONS AUTHORED BY CHRISTOPHER W ARMSTRONG
• PUBLICATIONS AUTHORED BY CHRISTOPHER W ARMSTRONG

Neurology, Rheumatology, Clinical Immunology, Haukeland University Hospital , Bergen, Norway

Dr Ingrid Gurvin Rekeland

Other Links

• Plos One
• ResearchGate

Genetics, Molecular Biology, Bioinformatics, Nova Southeastern University , Florida, USA

Dr Lubov Nathanson

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• ResearchGate

Professor - Paediatric Research Institute, Institute of Clinical Medicine, University of Oslo, Norway

Professor Ola Didrik Saugstad is a Norwegian pediatrician and neonatologist noted for his research on resuscitation of newborn children and his contribution to reduce child mortality.[2] Since 1991, he has been Professor of Pediatrics at the University of Oslo and Director of the Department of Pediatric Research at Oslo University Hospital, Rikshospitalet

Saugstad received the 2012 Nordic Medical Prize, is a member of the Norwegian Academy of Science and Letters and became a Knight First Class of the Order of St. Olav in 2010.

Other Links

• Wikipedia
• ResearchGate
• Institutefor Clinical Medicine, University of Oslo

Institute of Clinical Medicine, University of Oslo, Norway

Dr Asgeir Lande

Other Links

• Norges ME Forening

University of Oslo, Norway

Dr Katarina Lien graduated from the Faculty of Medicine, University of Oslo in 2000. I have clinical experience from primary care and psychiatry, and started working at the CFS/ME Centre at Oslo University Hospital in 2011.

She is particularly interested in pathophysiological mechanisms in chronic diseases.

In 2012 she received funding from The Norwegian Directorate of Health and The National Advisory Unit on CFS/ME, in order to gain experience on the use of CPET in patients with CFS/ME.

Currently, she is holding a research grant from the Norwegian ExtraFoundation for Health and Rehabilitation for the Ph.D. project “Cardiopulmonary exercise testing in patients with CFS/ME”.

She has been involved in the planning and implementation of the Rituximab trial RituxME, and is the local Principal Investigator at the CFS/ME Centre, Oslo University Hospital.

She is also engaged in CFS/ME patient education and information, and is a member of the Norwegian ME Association Scientific Advisory Board.

Other Links

• Norges ME Forening
Presentations: IACFS/ME Biennial Conference. October 2016. International Association for CFS/ME. Fort Lauderdale, Florida: Lien K, Johansen B, Veierød MB, Haslestad AS, Melsom MN, Kardel KR, Iversen PO. “Blood lactate increases more rapidly after a previous exercise challenge in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) than in healthy subjects” (manuscript in preparation). Publications: 1. Fluge, O., O. Mella, O. Bruland, K. Risa, S. E. Dyrstad, K. Alme, I. G. Rekeland, D. Sapkota, G. V. Rosland, A. Fossa, I. Ktoridou-Valen, S. Lunde, K. Sorland, K. Lien, I. Herder, H. Thurmer, M. E. Gotaas, K. A. Baranowska, L. M. Bohnen, C. Schafer, A. McCann, K. Sommerfelt, L. Helgeland, P. M. Ueland, O. Dahl and K. J. Tronstad (2016). "Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome." JCI Insight 1(21): e89376.

University of Otago, New Zealand

Professor Warren Tate from University of Otago in New Zealand - is an internationally respected biochemist, winner of the Royal Society of New Zealand's top science honour - the 2010 Rutherford Medal, and was also named a Companion of the New Zealand Order of Merit. His honour citation noted that Professor Tate was a molecular biologist, whose research had "revolutionised understanding" of how proteins were synthesised in living cells. His research had shown how proteins contributed to memory formation and neurological disease, and had important implications for HIV, Alzheimer's and chronic fatigue syndrome. Professor Tate is a Fellow of the Royal Society of New Zealand and of the New Zealand Institute of Chemistry. He has been a Fellow of the Alexander von Humboldt Foundation of Germany, and an International Research Scholar of the Howard Hughes Medical Institute of the United States.

Other Links

• ResearchGate
• Department of Biochemistry University of Otago, New Zealand
• Genetics Otago
• Tackling ME/CFS in New Zealand by the Principals of Precision Medicine - Journal of IiMER Volume 10 Issue 2016