IiMER Funded Research Projects



Our Foundation Project

IFR/UEA

A ROLE FOR A LEAKY GUT AND THE INTESTINAL MICROBIOTA IN THE PATHOPHYSIOLOGY OF MYALGIC ENCEPHALOMYELITIS

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DEFINING AUTOIMMUNE ASPECTS OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS)

UEA/Quadram Institute Biosciences

The aim of this PhD project is to test the hypothesis that ME is an autoimmune disorder originating in the gut as a consequence of altered intestinal permeability.

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Gut Viruses and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Quadram Institute Biosciences/UEA

This PhD project will investigate whether the underlying causes of ME are related to the presence of specific virus populations within the gut virobiota.

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Investigating Alterations in the Intestinal Virome in ME

Quadram Institute Biosciences/UEA

This PhD project will investigate and aim to answer important questions concerning the role of the enteric phage/virome in ME .

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Overview of Planned B-CELL RESEARCH/UK RITUXIMAB Projects

UCL/Quadram Institute Biosciences/UEA

B-CELL RESEARCH/UK RITUXIMAB CLINICAL TRIAL Projects

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Preliminary B-CELL Project

UCL

The preliminary B-cell study was designed to confirm and extend the earlier work of Dr Amolak Bansal on B-cells but using a different cohort of ME patients.

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B-cell research - PhD Project

UCL

Recent studies have identified abnormalities in the blood of patients, which have strengthened the suspicion that the immune system contributes to ME/CFS. Changes in populations of white blood cells, called B cells, in ME/CFS have been reported by several research groups including those in the UK. In addition, treatment with anti-B cell therapy using Rituximab by Fluge and colleagues in Norway have shown benefit to ME patients. This PhD project will investigate whether certain B cell products (antibodies and soluble factors) are involved in ME/CFS.

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Last Update September 2017


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