Our Foundation Project
Quadram Institute/UEA
A ROLE FOR A LEAKY GUT AND THE INTESTINAL MICROBIOTA IN THE PATHOPHYSIOLOGY OF MYALGIC ENCEPHALOMYELITIS
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DEFINING AUTOIMMUNE ASPECTS OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS)
UEA/Quadram Institute Biosciences
The aim of this PhD project is to test the hypothesis that ME is an autoimmune disorder originating in the gut as a consequence of altered intestinal permeability.
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Gut Viruses and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Quadram Institute Bioscience/UEA
This PhD project will investigate whether the underlying causes of ME are related to the presence of specific virus populations within the gut virobiota.
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Overview of Planned B-CELL RESEARCH/UK RITUXIMAB Projects
UCL/Quadram Institute Biosciences/UEA
B-CELL RESEARCH/UK RITUXIMAB CLINICAL TRIAL Projects
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Preliminary B-CELL Project
UCL
The preliminary B-cell study was designed to confirm and extend the earlier work of Dr Amolak Bansal on B-cells but using a different cohort of ME patients.
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B-cell research - PhD Project
UCL
Recent studies have identified abnormalities in the blood of patients, which have strengthened the suspicion that the immune system contributes to ME/CFS. Changes in populations of white blood cells, called B cells, in ME/CFS have been reported by several research groups including those in the UK. In addition, treatment with anti-B cell therapy using Rituximab by Fluge and colleagues in Norway have shown benefit to ME patients. This PhD project will investigate whether certain B cell products (antibodies and soluble factors) are involved in ME/CFS.
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RESTORE-ME - Clinical Trial of FMT
Quadram Institute Bioscience/UEA
To determine the efficacy and safety of faecal microbiome transplantation as for ME/CFS: RESTORE-ME.
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The intestinal virome and viral immune responses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients after faecal microbiota transplantation (FMT)
Quadram Institute Bioscience/UEA
This PhD project will investigate whether bacteriotherapy and manipulation of the gut microbiome can provide a possible treatment for ME.
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